Balding - Nature Genetics

SNP Heritability in Complex Traits

Reevaluation of SNP heritability in complex human traits, D Speed, N Cai, the UCLEB Consortium, M Johnson, S Nejentsev, D Balding, Nature Genetics (2017) doi:10.1038/ng.3865

David Balding recently published a paper with Doug Speed in Nature Genetics where they found that by analyzing imputed data for a large number of human traits, a model can be empirically derived that more accurately describes how heritability varies with minor allele frequency (MAF), linkage disequilibrium (LD) and genotype certainty.

Figure 1: Comparison of the GCTA and LDAK models

Figure 2: Relationship between heritability and MAF